HIPAA Compliance

Building HIPAA-Compliant Web Applications: Technical Requirements

Complete technical checklist for building HIPAA-compliant web applications. Learn about authentication, encryption, hosting, and audit requirements.

TWO44 Team
February 6, 2026
7 min read
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Building HIPAA-Compliant Web Applications: Technical Requirements

Introduction

Building a HIPAA-compliant web application requires more than standard security practices. Healthcare applications must meet specific technical requirements under the HIPAA Security Rule to protect electronic protected health information (ePHI). This guide outlines the essential technical requirements for compliant web applications.


Authentication and Access Control

Unique User Identification


Every user accessing ePHI must have a unique identifier. Implement multi-factor authentication (MFA) for all users. Consider role-based access control (RBAC) to enforce the minimum necessary standard.


Automatic Logoff


Implement automatic session termination after a period of inactivity. The exact duration depends on your risk assessment, but 15–30 minutes is common for healthcare applications.


Emergency Access


Define procedures for obtaining ePHI during an emergency. Document and log any emergency access for audit purposes.


Encryption Standards

Data in Transit


Use TLS 1.2 or higher for all data transmission. Enforce HTTPS across the entire application. Disable outdated protocols (SSLv3, TLS 1.0, TLS 1.1).


Data at Rest


Encrypt all databases and file storage containing ePHI using AES-256 or equivalent. Ensure encryption keys are managed securely and separately from encrypted data.


Secure Hosting Requirements

Choose cloud providers that offer HIPAA-eligible services and are willing to sign a Business Associate Agreement (BAA). Major providers like AWS, Azure, and Google Cloud offer BAA options. Ensure you configure services correctly—signing a BAA does not automatically make your configuration compliant.


Audit Logging

Implement comprehensive audit trails that capture:



  • User login/logout events


  • Access to patient records (view, create, modify, delete)


  • Failed access attempts


  • Configuration changes


  • Data exports and transfers

Protect audit logs from tampering and retain them for at least six years.


API Security

Secure all APIs that handle ePHI with authentication (OAuth 2.0, JWT), rate limiting, and input validation. Never expose PHI in URLs or query parameters. Use encrypted payloads for sensitive data.


Conclusion

HIPAA-compliant web applications require layered security: strong authentication, encryption everywhere, secure hosting with BAA, and comprehensive audit logging. Plan for compliance from the architecture phase rather than bolting it on later.


Need help building a HIPAA-compliant web application? Explore our healthcare software solutions or book a free consultation.